Considering Participation in a Clinical Trial ?


Why should you consider being a part of a clinical trial?
  • To be among the first to benefit from new treatments.
  • To gain access to promising new treatments that are not widely available.
  • To obtain high-quality care from doctors who are cancer experts.
  • To help future patients with the same type of cancer.
  • The approach being studied may be more effective than the standard approach.
What are some of the risks associated with taking part in a clinical trial?
  • New drugs or procedures under study are not always better than standard care to which they are being compared.
  • New treatments may have side effects or risks that doctors do not expect or that may be worse than those resulting from standard care.
  • Participants in randomized trials will not be able to choose the approach they receive.
  • To help future patients with the same type of cancer.
  • Health insurance and managed care providers may not cover all patient costs in the study (see the cost of clinical trials)
How are participants protected?
  • Research with people as the study subject is conducted according to strict scientific and ethical standards. Every clinical trial has a protocol, or action plan, which acts like a "recipe" for conducting the trial. The plan describes what will be done in the study, how it will be conducted, and why each part of the study is necessary. The same protocol is used by every doctor or research center taking part in a particular trial.
  • The government has a system designed to protect human research subjects. The Institutional Review Board must review and approve all federally funded trials. They also evaluate new drugs or medical devices.
  • Regulations require that the patients are fully informed about a study's treatment and tests. They are also informed about the possible benefits and side effects and risks. This process is called Informed Consent.
Institutional Review Board (IRB)

All clinical trials that are federally funded or that evaluate a new drug or medical device subject to Food and Drug Administration regulations are reviewed by an IRB. Many institutions require that all clinical trials, regardless of funding, are reviewed and approved by the IRB. The board includes doctors, researchers, community leaders and other members of the community. They review the protocol to make sure the study is conducted fairly and safely. The IRB decides how often to review a trial once it has begun. The IRB can stop a clinical trial if researchers are not following the protocol or if the trial appears to be causing undue harm.

Informed Consent

Informed Consent is a process in which you learn the important facts about a clinical trial before you decide whether or not to participate. This information includes details about:

  • Purpose of the study
  • Tests and other procedures used in the study
  • Possible risks of the study
  • Possible benefits of the study

In addition to talking with the doctor or nurse, you will receive a copy of the information to take home and discuss with your family before signing. If you agree to be in the study, you can leave at any time- either before the study starts or any time during the study or follow-up period. If new benefits, risks or side effects are discovered during the study, your doctor will inform you of these.

Here are some questions you may want answered by the doctor or nurse. Hopefully, the website will have answered many of your questions. If you still need additional information, a list of questions is provided for your use to get a better understanding of the study.

The Study
  • What is the purpose of the study?
  • Who is sponsoring the study?
  • Who has reviewed and approved the study?
  • How are the study results and safety of participants being monitored?
  • How long will the study last?
  • How will results be shared?
Possible Risks and Benefits
  • What are the possible short and long term benefits?
  • What are the short term risks, such as side effects?
  • What are the possible long term risks?
  • What are my options if I do not participate?
  • Will there be a group that take only takes the placebo?

Participation and Care
  • hat kinds of treatment, medical tests, or procedures will I have during the study?
  • Will treatments, tests or procedures be painful?
  • Will I be able to take my regular medications?
  • Where will I receive my medical care?
  • Can I still see my own doctor?
Personal Issues
  • How could being in a study affect my daily life?
  • What support is available for me and my family?
  • Can I talk to someone in the study?
  • Who can help answer questions from the insurance company or health plan?
  • What happens when the trial ends: can I continue treatment?

Berks Hematology Oncology Associates